Search results for "two-bottle choice"
showing 3 items of 3 documents
Acetaldehyde self-administration by a two-bottle choice paradigm: Consequences on emotional reactivity, spatial learning, and memory
2015
Abstract Acetaldehyde, the first alcohol metabolite, is responsible for many pharmacological effects that are not clearly distinguishable from those exerted by its parent compound. It alters motor performance, induces reinforced learning and motivated behavior, and produces different reactions according to the route of administration and the relative accumulation in the brain or in the periphery. The effective activity of oral acetaldehyde represents an unresolved field of inquiry that deserves further investigation. Thus, this study explores the acquisition and maintenance of acetaldehyde drinking behavior in adult male rats, employing a two-bottle choice paradigm for water and acetaldehyd…
Influences of social stress in the rewarding effects of mdma and alcohol
2015
La adicción a las drogas es un importante problema en nuestra sociedad con graves consecuencias jurídicas, médicas y sociales para los consumidores. Se trata de un trastorno caracterizado por la pérdida de control sobre el uso de la droga, su búsqueda compulsiva y la aparición de un estado emocional negativo en ausencia de la misma. El alcohol es la droga legal más consumida tanto por adultos como por adolescentes. Por otra parte, entre las sustancias ilegales, los datos epidemiológicos apuntan que el éxtasis o MDMA es una sustancia ampliamente consumida entre los adolescentes y adultos jóvenes sobre todo en fiestas “rave” donde los consumidores pasan horas, incluso días, haciendo uso de es…
Continuous and Intermittent Alcohol Free-Choice from Pre-gestational Time to Lactation: Focus on Drinking Trajectories and Maternal Behavior
2016
Background: Alcohol consumption during pregnancy and lactation induces detrimental consequences, that are not limited to the direct in utero effects of the drug on fetuses, but extend to maternal care. However, the occurrence and severity of alcohol toxicity are related to the drinking pattern and the time of exposure. The present study investigated in female rats long-term alcohol drinking trajectories, by a continuous and intermittent free-choice paradigm, during pre-gestational time, pregnancy, and lactation; moreover, the consequences of long-term alcohol consumption on the response to natural reward and maternal behavior were evaluated. Methods: Virgin female rats were exposed to home-…